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Stereospecificity of pig liver esterase in the hydrolysis of racemic esters derived from 1,8-cineole
(Instituto de Investigación de las Ciencias Exactas Físicas y Naturales, 2006-12)
The efficient synthesis of biological active compounds, so much natural as not natural, frequently requires chiral syntons. Enzymes as chiral catalysts are widely used for this purpose owing to the fact that it is usually ...
Isolation of ibuprofen enantiomers and racemic esters through electrodialysis
(Elsevier Science, 2021-01-15)
The electrodialysis of pure rac-ibuprofen and the products of the enzymatic kinetic resolution of the profen were investigated in order to establish the best conditions for the separation of the ibuprofen from the ethyl ...
Deracemisation processes employing organocatalysis and enzyme catalysis
(Wiley VCH Verlag, 2020-03)
Deracemisation methods have demonstrated their importance in the preparation of chiral compounds in the last few years. In order to resolve a racemic mixture in a dynamic sense, one enantiomer of the starting material can ...
Pharmacokinetics and synovial fluid concentrations of flurbiprofen enantiomers in horses: chiral inversion
(Wiley Blackwell Publishing, Inc, 2005-02)
Flurbirpofen (FBP), a member of the 2-aryl propionate nonsteroidal anti-inflammatory drug class, has potent anti-inflammatory and analgesic properties. The commercial preparation is a racemic mixture of the R(−) and S(+) ...
Kinetic profiles of the stereoselective reduction of acetophenone and its derivatives promoted by Galactomyces candidus GZ1. A mechanistic interpretation
(Elsevier, 2019-01)
A mechanistic interpretation of the kinetic profiles obtained for the stereoselective reduction of acetophenone promoted by Galactomyces candidus GZ1 under aerobic and anaerobic conditions was made. Based on experimental ...
Chemometrics-assisted study of the interconversion between the crystalline forms of nimodipine
(Elsevier Science, 2018-09)
Nimodipine (NIM) is a calcium channel-blocking agent, which in the solid state exhibits two crystalline modifications, Mode I and Mode II. The first one is a racemic mixture, while the second is a conglomerate. Because the ...
Enantioseparation of polar pesticides on chiral capillary columns based on permethyl-β-cyclodextrin in matrices of different polarities
(Elsevier Science, 2018-07)
This work describes the influence of different achiral polymers used to dissolve permethyl-β-cyclodextrin (PM-β-CD) on the gas chromatographic enantioresolution of racemic mixtures of polar pesticides (mecoprop, dichlorprop, ...
Permethylated β-cyclodextrin in liquid poly(oxyethylene) as a stationary phase for capillary gas chromatography
(Elsevier Science, 2009-10)
This paper reports the study of poly(oxyethylene) as a solvent for heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (PM-β-CD) and the potential of these mixtures for constructing enantioselective gas chromatography columns. ...
Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration
(Elsevier Science, 2018-03)
A method to optimize the ligand concentration [S] in the background electrolyte of capillary electrophoresis separations is presented. It is based on the use of a model which predicts apparent electrophoretic mobilities ...
An in silico analysis of Ibuprofen enantiomers in high concentrations of sodium chloride with SARS-CoV-2 main protease
(Taylor & Francis, 2021-01)
2020 will be remembered worldwide for the outbreak of Coronavirus disease (COVID-19), which quickly spread until it was declared as a global pandemic. The main protease (Mpro) of SARS-CoV-2, a key enzyme in coronavirus, ...